A Holiday Message from the Chris Rule Foundation

All of us at The Chris Rule Foundation would like to take this opportunity to wish you and yours the best this Holiday Season. Our hope is that 2017 is filled with promise and blessings in all that you do.

This letter also is being sent to thank you for your past generosity and support. Those heartfelt thanks also come from the individuals, family members and organizations we had the privilege to help in 2016 because of your donations. Our hope and purpose has always been that we might help save the loved one of someone else fighting the disease of depression.

As we near the end of 2016, we ask for your support to give what you can now to help those in need of the hope of recovery and a new life. Your donation will help The Chris Rule Foundation fund depression treatment research and provide support to organizations offering community programs promoting awareness of depression treatment.

You are invited to join the many other citizens who will give to a non-profit on Tuesday, December 6, on Colorado Gives Day. All donations made to The Chris Rule Foundation are tax deductible. Please consider helping us provide an opportunity for hope to individuals and family members searching for answers and help in fighting the devastating disease of depression.

All donations should be made payable to: The Chris Rule Foundation, 4600 S Ulster St, Ste 850, Denver, CO 80237. If you would like more information or need to contact us, please email Jack Rule at Your gift today may just save a life.

In Gratitude and Thanks,

Jack Rule, President
The Chris Rule Foundation

University of Michigan: Progress toward a genetic profile of bipolar disease

New stem cell research on bipolar disorder, conducted by a team of researchers with the Heinz C. Prechter Bipolar Research Fund at the University of Michigan, is helping to uncover the molecular mechanisms underlying this potentially disabling illness. Taking simple skin cells about the size of a pencil eraser, researchers at Michigan have coaxed those cells back to an early developmental state, an “induced pluripotent stem cell”  (iPSC) and then to grow them into nerve cells, creating the first stem cell derived neural lines generated from patients with bipolar disorder. The neurons developed from people with bipolar have different genetic patterns in their membrane receptors.  This affects how neurons react to stimuli and nerve signals.

This suggests that there are fundamental differences in the brains of individuals with bipolar. The implications of this work are profound. This research will lead to fundamental changes in the understanding of the biology and function of the brain. These cell models will allow for the testing of new drugs and treatments and will open the door to a new era of highly personalized medicine and the ability to optimally match treatments to individuals.

“We are very excited about studying cellular mechanisms; this technology brings us to essence of the biology of nerve cells from people with bipolar disorder,” said Melvin McInnis, M.D., the Principal Investigator of the Prechter Bipolar Research Projects.

The mission of the Heinz C. Prechter Bipolar Research Fund is to detect depression and bipolar disorders earlier, treat them more effectively, prevent recurrences and progression, counteract stigma, and improve public policy. For more information, visit

A Powerful TED Talk on Depression

CU Depression Center and the Chris Rule Foundation

The Chris Rule Foundation is a major supporter of the University of Colorado Depression Center.  The Depression Center is the only comprehensive center of its kind in the Rocky Mountain west, combining the best clinical care for children and families, cutting-edge research and a wide array of community education and suicide prevention programs.  CRF funds have been used in a variety of ways to conduct suicide prevention programs across the state.  In the past year, the Center has delivered suicide prevention programs in diverse settings including Denver Academy, Kent Denver school, multiple businesses and hospitals, community groups in Limon and Ft. Morgan, at community centers throughout the Denver metro area.  Additionally, three Denver karate studios have made completion of the Center’s suicide prevention program a requirement to test for black belt.  The Center is also leading the effort to implement the National Strategy for Suicide Prevention in Colorado; something that no other state has accomplished.  Depression Center staff and faculty are active in Colorado’s suicide prevention community, having served on the boards of the American Foundation for Suicide Prevention, the Suicide Prevention Coalition of Colorado and the Carson J Spencer Foundation.  Please take a moment to view the following video produced by the CU Depression Center.  Please feel free to share this video with your friends and family.

Foundation Focus Areas

  1. 1. Early Detection and Treatment
  2. 2. Cognitive Behavioral Therapy
  3. 3. Medication
  4. 4. Genetic Testing

7 Ways to Spot Depression

  1. 1. Constant sadness–more tearful or crying more easily than usual
  2. 2. Trouble sleeping or sleeping a lot more than usual
  3. 3. Decreased interest in activities
  4. 4. Feeling hopeless, guilty , worthless for no reason
  5. 5. Increased irritability
  6. 6. Low energy, fatigue
  7. 7. Significant weight change


Research Findings

Online Tools

Where to Seek Help

3 responses to “Resources”

  1. What a wonderful tribute to Chris last night. Congratulations to the board and all those who came out to help create this tremendous legacy.

  2. Lauren Vitalie says:

    Thought this would be helpful:10-11-12
    Today is National Depression Screening Day, where clinicians at more than 1,000 locations nationwide will offer free, anonymous assessments for depression.

    To find a participating site or to take a screening online, visit

    Click here for more information:

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